Sam's tale

Radical-Mediated Enzymatic Methylation: A Tale of Two SAMS

Methylation is an essential and ubiquitous reaction that plays an important role in a wide range of biological processes. Most biological methylations use S-adenosylmethionine (SAM) as the methyl donor and proceed via an S(N)2 displacement mechanism. However, researchers have discovered an increasing number of methylations that involve radical chemistry. The enzymes known to catalyze these reac...

SAMS: Strategic Account Management System

The selling of sophisticated equipment is very different from the sale of simple products and requires a considerable amount of strategizing to achieve success. In clear recognition of this fact, Canon has a sales strategy training program that uses SPIN@ selling methodology to train major account sales representatives. However, this training gets quickly lost in the multitude of daily tasks th...

Chromatin: Polycomb Group SAMs Unite

Polycomb Group (PcG) proteins assemble a chromatin state that maintains developmental gene repression. A new study combining structure and in vivo analysis details a molecular network from DNA recognition to PcG recruitment, highlighting the essential role of Sterile Alpha Motifs.

Digital Necrosis: A Hoarder’s Tale

SAMS: Synchronous, Asynchronous, Multi-Synchronous Environments

In the context of cooperative work, a team alternates divergence phases where each member works in insulation on copies of objects and convergence phases during which the group reconciles and validates data. To support this style of working, we propose the concept of SAMS environments. A SAMS environment allows team members to work in Synchronous, Asynchronous or Multi-Synchronous mode while en...